Objectives: To establish whether the patients with brain damage and the risk of brain death occurence have been treated according to professional recommendation, whether everything is done according to legislation in case of brain death, what kind of problems do medical workers who take care of potential organ donours encounter. Study outline: A retrospective study. Participans and methods: Examinees are patients with brain damage of a known cause treated at the ICU of the Anestesiology Clinic of the Clinical Hospital Centre Osijek (KBC Osijek) since 1 January 2005 until 31 December 2015, for whom the brain death was proven. The relevant data (coma cause, treatment course, the records of conducted tests, death certificate, the explantation consent) was collected from disease history. Results: Brain death was proven with 130 examinees. In 68,46 % of the cases coma cause was spontanious, and in 31 % of the cases coma cause was traumatic cerebral hemmorrhage. Over 90% of the examinees were in an areflexic coma upon the arrival to the ICU. With all the examinees brain death was proven by the clinical studies and cerebral scintigraphy. Explantation was done in 70% of the cases. A positive trend of brain death incidents was noticed, withous changes in the trend of explantation incidents and a negative trend of opposition to organ donation. Conclusion: All examinees were treated according to professional guidelines. In cases where the condition pointed to the loss of brain functions, brain death was proven, according to legislation, by clinical tests and cerebral scintigraphy. The explanted patients were donours whose families signed the consent. Enlisting a larger number of potential donours and a weaker opposition to the organ donation did not significantly affect the number of conducted explantations.