Objectives: The aim of this study was to research and describe the clinical features of headache in children and to assess the possible predictive value of symptomatology on the duration and course of headache in children. Study design: The study is designed as a cross – sectional study. Participants and Methods: The research included 100 participants who came to the Neuropediatric Polyclinic of the General County Hospital in Požega with the symptoms of headache, in the period from 2012 to 2021. General information about the patient and the clinical characteristics of the headaches were singled out from the medical documentation. Statistical analysis was performed by MedCalc® Statistical Software version 20.111 (MedCalc Software Ltd, Ostend, Belgium; https://www.medcalc.org; 2022). Results: The median age of the patients was 13 years. A slight predominance of the female gender (68 %) compared to the male gender (32 %) was recorded. Regarding the quality of the pain, the most frequent were continuous pain (29 %) and dull pain (28 %). Among the associated symptoms, the most frequent ones were vomiting (20 %) and nausea (15 %). Headache occurs in the largest number of patients, 44 (44 %), regardless of the time of day. Patients with a severe clinical picture have associated symptoms with the headache, especially vomiting and nausea, they describe the headache as throbbing or pressing, and the headache wakes them up at night. There were significantly more patients with a severe clinical picture in whom there was no improvement in symptoms after one year (46.5 %). Conclusion: Clinical characteristics are of great diagnostic importance, both in neurology and in neuropediatrics. Based on clinical characteristics such as pain quality, severity of the clinical picture and associated symptoms, it is possible to predict the duration and course of the headache.