OBJECTIVE: The main goal of this study was to determine the intensity of pain, acceptance of pain, and the incidence of anxiety and depressive symptoms in patients with neuropathic pain, before and after two weeks of acupuncture and physical therapy. STUDY DESIGN: This study is organized as a cross-sectional study. PARTICIPANTS AND METHODS: This study included 40 patients who are being treated for underlying pain syndrome with neuropathic component. The patients were treated at the Pain Management Department of the Clinic for Anesthesiology, Reanimation and Intensive Care of the University Hospital Centre in Osijek. Data were collected using an anonymous questionnaire including anamnestic questionnaire, numerical rating scale (NRS), pain detect questionnaire (PDQ), chronic pain acceptance questionnaire 8 (CPAQ-8) and depression anxiety stress scale 14 (DASS-14). Patients completed questionnaire before and after two weeks of therapy. RESULTS: Amongst the participants, 80 % were women and 87 % were over 40 years old. In the subjects, a significant decrease in the pain intensity rating was observed after the therapy compared to the period before the therapy, despite this, the median of pain acceptance rating did not change significantly. Upon completion of therapy, there was a significant decrease in the overall anxiety score of the patients, but there was no significant decrease in the depression score. The distribution of patients within the categories according to the severity of anxiety and depression was also not significantly modified. CONCLUSION: Despite the fact that pharmacological treatment combined with physical therapy and acupuncture can lead to a reduction of pain intensity in patients, it is necessary to involve a multidisciplinary team in treating these patients, which would focus not only on solving physical complaints, but also on solving psychological problems experienced by these patients.