Objectives: The objectives of this study were to evaluate adherence to topical therapy, knowledge about potential side effects and the association of these factors with demographic and socioeconomic indicators, dermatological conditions, and other medications in chronic therapy. Study Design: The survey is designed as a cross-sectional survey. Participants and Methods: The study included 117 participants who were using or had used topical therapy, and they were assessed in a dermatology clinic. Data regarding age, gender, education, medications in chronic therapy, knowledge of medication side effects, dermatological conditions, and duration of local therapy were collected for each patient. Adherence data were collected using the TTAQ questionnaire. Results: Nearly one quarter of the patients was unaware of the side effects of the therapy they were using, and among those who were aware, less than 50 % learned about them from healthcare professionals, while 33,4 % obtained the information from the internet. The majority of patients occasionally read the medication instructions, report side effects to their doctors, and prefer using natural treatment methods. Students and individuals who always read the patient information leaflet rated Benefit to patients and Treatment satisfaction higher compared to unemployed individuals and retirees. Men attributed better tolerability to their current therapy, while older patients found it more challenging to adhere to the current therapy compared to the previous one. The median score for each domain was significantly closer to the highest rating than the lowest. Conclusion: Age, gender, reading medication instructions, and employment status have been identified as factors influencing adherence to topical therapy, which can be considered satisfactory on average within this patient group. Although most patients claim to be aware of the side effects of their therapy, less than half of them learned about them from their healthcare providers, with a significant number obtaining information fromthe internet.