Association of depression, anxiety, and stress with N-glycosylation of immunoglobulins G in students Objectives. The study aimed to examine the prevalence of depression, anxiety, and stress symptoms among students, and investigate their association with immunoglobulin G (IgG) Nglycosylation. Study design. Cross-sectional study. Participants and methods. The study involved 82 students (23 males and 59 females). The DASS 21 (Depression, Anxiety, and Stress Scale 21) was used to assess the prevalence depression, anxiety, and stress symptoms. IgG was isolated from plasma, and the composition of N-glycans was analyzed by capillary gel electrophoresis. Results. Depression symptoms were reported in 38 % of participants, anxiety in 50 %, and stress in 41.2 %. Female students exhibited higher levels of stress than male students (P = 0.028). No difference in N-glycans was observed between participants with symptoms of depression and those without symptoms of depression. Participants with anxiety symptoms expressed lower levels of A2B[3]G1 (digalactosylated biantennary with branching N-acetylglucosamine) than students without symptoms of anxiety (P = 0.016). Students with stress symptoms had higher levels of A2[6]G1S1 (monogalactosylated, monosialylated biantennary) (P = 0.006) and FA2G2 (core fucosylated, digalactosylated biantennary) (P = 0.005), but lower levels of A2G2[6]S1 (monogalactosylated, monosialylated biantennary) (P = 0.03), FA2 (core fucosylated, agalactosylated) (P = 0.038), FA2B (core fucosylated, agalactosylated biantennary) (P = 0.014) and A2B[3]G1 compared to students without stress symptoms (P = 0.002). Conclusion. A high prevalence of depression, anxiety, and stress symptoms was observed within the student population. Differences in IgG N-glycans were found between participants who had symptoms of anxiety and stress and those who did not have these symptoms.