Objectives: To examine whether there is a difference in the number of patients with colorectal cancer before and during the COVID-19 pandemic, and to examine whether there is a difference in the stage of colorectal cancer before and during the COVID-19 pandemic. Study Design: Cross-sectional study with historical data Participants and methods: The participants are patients who were diagnosed with colorectal cancer in the period from 2019 to 2022 at the Clinic for Oncology and Radiotherapy of the Clinical Hospital Center Osijek. Patients with more than one primary localization of colorectal cancer were excluded from the study. Results: The study included 857 patients diagnosed with colorectal cancer. Of the total number of patients, 278 (32.4%) patients were diagnosed before the COVID-19 pandemic, and 579 (67.6%) during the COVID-19 pandemic. Most patients, 282 (32.9%) were diagnosed at stage III, while there were a total of 227 (26.5%) patients with stage IV. Regarding the localization of the tumor, in 304 (35.5%) cases it was the rectum, significantly more often before the COVID-19 pandemic, in 162 (18.9%) cases it was the rectum and sigmoid colon, and 120 (14%) patients had its localization in the sigmoid colon, significantly more often during the COVID19 pandemic. Conclusion: The COVID-19 pandemic did not significantly affect the reduction in the number of diagnosed patients with colorectal cancer and the incidence of advanced stages of the disease at the Clinical Hospital Center Osijek.