Objectives: The aim of this study was to compare the incidence of dreaming between men and women after propofol anesthesia. We also investigated differences in demographic characteristics, duration of anesthesia, propofol dose, arterial blood pressure levels, pulse and bispectral index between those who have had dreams and those who have not. Participants and methods: Total of 95 patients undergoing gastrointestinal endoscopy at University Hospital Osijek participated in this prospective observational study, there were 40 men and 55 women. Written informed consent was obtained from all participants. Demographic characteristics were noted before anesthesia. Propofol dose was titrated individually until a patient was unresponsive to painful stimuli while maintaining spontaneous breathing. Arterial blood pressure, pulse and bispectral index were monitored in typical intervals. On the emergence from anesthesia, patient's face expression was rated numerically by the examiner. Afterwards, the patients were asked whether their dreams had been pleasant or not. Results: The presence of dreams was registered in 40 patients; 20 men and 20 women. There were no significant differences in demographic characteristics, duration of anesthesia, propofol dose, pulse and bispectral index values between dreamers and non-dreamers. Systolic arterial pressure was significantly lower at the moment of emergence in those who have had dreams (105.3 with SD 17,9 vs. 114.4 with SD 22.8 mmHg, t-test, P=0,038). There was a significant difference between the observer’s rating of facial expressions in the group with pleasant dreams and in non-dreamers (1.7 with SD 1.0 vs. 1.0 with SD 1.3; t-test, P=0.005). Conclusion: Patients who have had dreams emerged from anesthesia with significantly more pleasant face expression and lower systolic blood pressure than those who haven’t. There were no other significant differences between the groups.