Objective: The main objective of the study was to determine the side effects in using antipsychotics in patients with schizophrenia, hospitalized at the Clinical Hospital Center Osijek, at Psychiatric Clinic in 2016, as well as categorizing side effects by type (motor and metabolic side effects) and antipsychotics (typical and atypical). Furthermore, the aim was to evaluate the influence of side effects on the course and the outcome of the treatment. Study design: Cross-sectional study Participants and methods: The study included 120 patients with schizophrenia according to MKB-10 criteria, hospitalized at Clinical Hospital Center Osijek, at Psychiatric Clinic in 2016. Data on age, sex, diagnosis, the type and the length of the use of antipsychotics were taken from patients’ medical records. Metabolic and motor side effects were recorded and certain actions were performed in order to reduce them. In addition, we estimated the impact of side effects on the course and the outcome of the treatment, i.e. patients’ response to the applied therapy. Results: Out of 120 patients, 82 (68.3%) reported side effects. Among metabolic side effects, the most common was elevated cholesterol level, found in 53 (65%) patients, and the most common motor side effect was parkinsonism, present in 8 (10%) patients. The most commonly used atypical antipsychotics were risperidone, clozapine, paliperidone, and among the most commonly used typical antipsychotics were promazine, flufenazine and haloperidol. Patients with schizophrenic acute psychotic disorder are more often treated with typical antipsychotics. Conclusion: Side effects are relatively common in the use of antipsychotics, which is quite important to take into consideration due to the influence of side effects on the course, but also the outcome of the treatment. Appropriate antipsychotics should be selected individually for each patient, so we have to take into account their potential risks of the development of certain side effects.