FUNGAL INFECTIONS IN ICU PATIENTS Objectives: The main objective of this study was to investigate the epidemiology, etiology and clinical characteristics of fungal infections in patients who have resided in the ICU, Clinical Hospital Osijek (2012.- 2014.), to determine the type of pathogen, the most common sites of isolation of pathogens, risk factors for fungal infection and its outcomes. Study design: The study was retrospective. Participants and methods: The subjects were patients treated in the ICU of Anesthesiology, Resuscitation and Intensive Care, Clinical Hospital Osijek in the period 2012.-2014. Data were collected from the archives. Data was relating primarily to the fungus isolates from different samples, information about the diagnosis of fungal colonisation, treatment and patient clinical caracteristics before and during staying in ICU. Results: The most frequent species in both infected and colonized patients was C. albicans, and than C. glabrata. The highest mortality rate in the group of infected patients had C. albicans (60%) and it was mostly isolated from the tracheal aspirate, and then the urine. It was noticed that the number of colonized patients is significantly higher than the number of patients who are infected with a Candida spp. Male and sepsis were observed as risk factors for infection, and the association of age, sex, gastrointestinal comorbidities, receipt of the department of abdominal surgery, recent surgery and previous use of antibiotics have not been proven as statistically significant factors associated with letal outcome of the patient. Conclusion: Candida albicans is fungal pathogen that causes the most colonization, infection and mortality of candida infected patients staying in the ICU. The incidence of fungal infections over the years in Osijek ICU during the period 2012.-2014. has decreased, contrary to increasing infections of this kind which have been published in the articles of a major worldwide clinical centers. Male gender and sepsis in patients are the only observed as a risk factor for the development of fungal infections.