Aims: to determine the satisfaction with the quality of life through self-assessment of different life areas as well as the differences considering gender, age, the time past since the transplantation and present side-effects of the treatment, to determine to what degree transplantees, regarding ethiology, comply with medical recommendations and to determine the relationship between the quality of life and social support. The examinees and methods: 103 examinees controlled in Translpantation clinic KB “Merkur” are included in this cross-sectional study. The instrument of research was an anonymous questionnaire consiting of fifty-six questions and covering WHOQOL-BREF, Personal Wellbeing Index–Adult, Multidimensional Scale of Perceived Social Support and a questionnaire with socio-demographic and medical data. The answers are defined on Likert-type scale for WHOQOL- Bref from 1-5, PWI 1-10 and MSPSSA 1-7. Results: The examinees rated overall satisfaction with their life with median 80 (interquartile range 60-90). There is a weak, but significant negative connection of the examinees’ age with the overall scale of the quality of life (Spearman’s correlation coefficient Rho = -0,207, P = 0,04) and mental health (Spearman’s correlation coefficient Rho = -0,209, P = 0,04). Examinees without side-effects are significantly more satisfied with all domains except for the domain of social relationships. The quality is significantly higher in all domains except for the domain of physical health with examinees with higher level of perceived social support. Conclusion: The quality of life of people who have undergone liver transplantation is in accordance with that of overall population in the Republic of Croatia. Older examinees are in a poorer overall and mental health condition. People with present side-effects are significantly more unsatisfied with the quality of life. High level of perceived social support provides significantly higher quality of life.