Study goal: The aim of the research was to assess by means of a validated questionnaire the level of the knowledge about the information-technology system and online safety issues associated with privacy among the students of the Medical School in Osijek as well as to make an assessment of the extent to which their behaviour on the Internet is potentially risky. Study design: The conducted study was implemented as a cross – sectional study. Research paricipants and methods: The students of the Medical School in Osijek who took part in the research on the voluntary basis were the classes of the year-one students and one class of the year-two students both female and male respondents. The research was carried out by means of a validated scientific questionnaire “ The questionnaire on the knowledge and risky behaviour of the users on information-technology system“ (UISAQ) that includes 33 questions/statements divided into six subgroups measured in numerical values/points against a Likert Scale with a range from 1 to 5 where the responses are given different values. The respondents were given a choice of 4 pre-coded statements on demography-associated information. The research was conducted in May 2017. Results: The collected data regarding 92 respondents were processed to indicate that the female respndents are significantly more aware that their personal details on the Internet might be stolen, as opposed to the male respondends. Statistically, in comparison with the findings of the previous surveys, the students of the Medical School in Osijek behave significantly different with regard to giving their personal details associated with the access to the internet. Conclusion: Although the pupils showed an adequate level of knowledge on Internet safety, the level of behaviour of the students at the Osijek Medical school was noticed relative to the reference values. It is necessary to inform and raise awareness of possible risks on the Internet and to carry out further education.