OBJECTIVE: The aim of this study was to determine the percentage of patients with negative attitude towards generic drugs in a population sample of patients with at least one chronic disease for which they receive long-term therapy and to evaluate the attitudes toward generic drugs in relation to gender, degree of education and the number of medications in chronic therapy. STUDY DESIGN: cross-sectional study STUDY PARTICIPANTS AND METHODS: The collected data were analyzed based on interviews and anonymous questionnaires filled out by patients in the General Practitioners’ clinics of the Osijek Health Center. One hundred patients participated in the research. The anonymous questionnaire was compiled for the purpose of this study and it contained the following data on the participating subjects: birth year, gender, body weight, height, education degree, clinical diagnosis, time of the onset of their condition and brand names and doses of medications in chronic therapy. Thereafter, a series of specific questions followed, analyzing the attitude of patients with chronic illnesses toward generic drugs. RESULTS: A total of 69 (69%) participants agree with the statement that their opinion of the original drugs is positive. The highest number of participants, 16 (16%), partially disagree with the statement that they experience more pronounced adverse effects when the therapy is changed. Fourteen (14%) participants could not decide whether their opinion on generic medicines is negative. Five (5%) participants agree that generic drugs could be harmful to human health. There is no significant difference in the attitudes towards generics in relation to gender, degree of education or the number of medications in chronic therapy. CONCLUSION: Patients do not generally have a negative view on generic therapy.