Introduction: Substance abuse is a serious health and social problem, both globally and in Croatia. An additional problem is easier access to addictive substances and the emergence of new forms of addiction, especially among students. In this paper, we studied the type and frequency of consumption of addictive substances among the students of the Polytechnic in Šibenik, as well as psychological and social factors related to substance abuse. Objectives: To determine the prevalence of risk behaviours, including smoking, alcohol and psychoactive drug consumption, gambling and Internet addiction among students, as well as the characteristics of the respondents. Respondents and methods: The survey was conducted from March to May 2018 on the students of the Polytechnic in Šibenik using a questionnaire consisting of 46 questions. The sample included 330 students. The questionnaire was anonymous and approved by the Polytechnic. Results: 36.5% of the students smoke cigarettes, while more than half of them do not smoke. Marijuana is consumed by 16.5% of the students and it is the most common drug among them. 86% of the students sometimes consume alcohol or drink at least once a week. Girls smoke more cigarettes, whereas boys consume more alcohol. They spend 4 or more hours a day on the Internet; girls more than boys. Gambling was more prevalent among boys than girls. Conclusion: It is necessary to continue tracking data and developing a comprehensive program of health promotion and drug prevention as well as an effective strategy to prevent risk behaviours.