Objectives: Examine the difference between Glasgow prognostic inflammatory index of the groups and examine the influence of risk factors affecting the mortality of patients treated with hemodialysis. Study Design: Case-control study. Respondents and Methods: The study was done on 40 patients with chronic kidney disease in the hemodialysis program. Patients were divided into two groups: patients who are still alive and go to hemodialysis and patients who died during the hemodialysis treatment. Demographic data was collected from medical records and laboratory parameters from laboratory findings. After the collected parameters of CRP, albumin, calcium, phosphorus, LDL and cholesterol, based on statistical data processing, the Glasgow prognostic index was calculated using CRP and albumin, and the following conclusions were drawn. Results: The most common diagnoses in patients are diabetic nephropathy, chronic glomerulonephritis, and with regard to comorbidities, most frequent are arterial hypertension and type 2 diabetes. CRP values are significantly increased in the deceased patients, but the cholesterol and LDL values are significantly lower. Reduced values of calcium are present in 55% of patients. The majority of patients, 62.5% of them have elevated values of phosphorus in comparison with the reference value. Glasgow prognostic inflammatory index 2, CRP values> 10 mg / L and albumin <35 g / L is present in 62.5% of patients. Conclusion: The mortality rate of patients treated by hemodialysis increases with greater inflammation intensity. Patients with chronic renal disease treated with hemodialysis have an increased risk of cardiovascular risks, and therefore increased mortality.