Objectives of the study: to examine the way of storing, preparing, applying and documenting the drugs, and to investigate how safe the management of drugs in the County Hospital of Čakovec is to detect weak points. Study Plan: Cross-Study Subjects and Methods: The method of self-generated anonymous survey included 130 nurses / technicians at the Department of Anesthesiology, Reanimation and Intensive Medicine with ICU and Department of Surgery. The research was conducted in October 2017. RESULTS: The respondents are aware of their responsibility for the correct storage of the drug and how much improper manner of storage affects the patient's safety. Responses are uniform across departments, apart from the fact that there is a special refrigerator for storing drugs and proper documenting its temperature. At least one of the subjects asks for a drug use permit and informs the patient about possible side effects, and a significant number of them mentioned the spatial inadequacy of the drug preparation at their ward. Most respondents complained that they were not sufficiently educated to use drugs via the femoral / epidural catheter. Vital signs before and after drug administration are not adequately measured, and verification whether the patient swallowed the drug that was given is rather poor. Respondents recognize deficiencies in the evidence of side effects and allergy on the nursing resignation letter and complete information on medications for each individual patient in the nursing report booklet. Conclusion: The mode of administration of medicines in the County Hospital of Čakovec is in line with the literature and the rules of the profession. The ability to further improve the quality of work is to provide adequate space for drug preparation in each department, improve training on the treatment of femoral and epidural catheters, and remove all distractors from the environment during therapy division, check vital signs before and after drug administration.