Objectives of the research: to investigate the role of a lifelong learning in self-esteem of nurses, and to determin if there is a difference in the self-esteem of the nurses considering the level of formal education, chronological age, gender, place of residence and the length of work experience. Study draft: Cross – sectional study Respondents and Methods: The nurses and the medical technicians participated in the study, 120 of them who work in different departments at 'Dr. Tomislav Bardek' general hospital in Koprivnica. The research was carried out in the period from October until December 2017. The questionnaire Rosenberg self – esteem scale was used in the research. All items are answered using a 5 point Likert scale format. Results: Most of the respondents live in the town, they have completed secondary education and they work in shifts. Men show a little higher level of self – esteem but the difference isn't significant comparing to women. As the level of education is higher so is the level of self – esteem, but without any statistical significance. The highest level of self – esteem have the respondents younger than 30 years, and the lowest 50 and over. A higher level of self – esteem is shown by those who live in the town, but the difference is not significant. As the length of work experience increases, self – esteem is falling, but the differences aren't significant. Conclusion: According to the research we can make a conclusion that there is no statistically significant difference in the self – esteem of nurses considering the level of formal education, chronological age, gender,place of residence and the work experience. Self – esteem is a little higher in medical technician and is growing with an increase of the level of education but without any statistical significance.