OBJECTIVE: The objective of this study was to determine the frequency of gastric symptoms during an acute migraine attack and to determine the way in which they affect the choice and method of treatment, considering the reduced effectiveness of oral delivery, as well as to investigate the quality of life of patients suffering from migraines. STUDY DESIGN: This is a cross sectional study. PARTICIPANTS AND METHODS: The study included 30 participants suffering from migraines who are being treated at the Headache Clinic of the Neurology Department of the University Hospital Centre Osijek. The research tools applied in this study include an anonymous questionnaire designed specifically for this study, which was used to gather the participants’ demographic information, the therapy information, and the information on the clinical features of the migraine attack, as well as the SF-36 (Short Form Healthy Survey). RESULTS: Gastric symptoms have been reported by 28 (93 %) of the study participants during an acute migraine attack. Gastric symptoms hinder the administration of oral therapy for 18 (60 %) of the participants. The therapy is taken orally by 28 (94 %) of the participants, and 19 (63 %) of the study participants continue to use the same method of treatment delivery even in case of nausea and/or vomiting. The gastric symptoms do not have a significant effect on the choice and effectiveness of the analgesic. The difficulties in therapy administration does not affect the quality of life in any of the areas of physical or mental health. . CONCLUSION: Gastric problems are common during acute migraine attacks and they hinder oral therapy administration. The hindered therapy administration does not significantly affect the choice of analgesics and their effect on the reduction of pain intensity. The quality of life is not significantly reduced due to the hindered therapy administration.