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master's thesis
Laboratorijska dijagnostika Gravesove bolesti
2019. urn:nbn:hr:152:963520
Bardak, Ivana
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

Cite this document

Bardak, I. (2019). Laboratorijska dijagnostika Gravesove bolesti (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:963520

Bardak, Ivana. "Laboratorijska dijagnostika Gravesove bolesti." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2019. https://urn.nsk.hr/urn:nbn:hr:152:963520

Bardak, Ivana. "Laboratorijska dijagnostika Gravesove bolesti." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2019. https://urn.nsk.hr/urn:nbn:hr:152:963520

Bardak, I. (2019). 'Laboratorijska dijagnostika Gravesove bolesti', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 23 November 2023, https://urn.nsk.hr/urn:nbn:hr:152:963520

Bardak I. Laboratorijska dijagnostika Gravesove bolesti [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2019 [cited 2023 November 23] Available at: https://urn.nsk.hr/urn:nbn:hr:152:963520

I. Bardak, "Laboratorijska dijagnostika Gravesove bolesti", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:152:963520

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Metadata
TitleLaboratorijska dijagnostika Gravesove bolesti
Title (english)Laboratory diagnosis of Graves disease
AuthorIvana Bardak
MentorSanja Mandić (mentor)
Committee memberLjubica Glavaš-Obrovac (predsjednik povjerenstva)
Committee memberVatroslav Šerić (član povjerenstva)
Committee memberSanja Mandić (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2019-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Biochemistry
Abstract
CILJ ISTRAŽIVANJA. Cilj istraživanja bio je usporediti dijagnostički značaj TRAB i TSI testa u dijagnosticiranju pacijenata s Gravesovom bolesti. USTROJ STUDIJE. Studija je ustrojena kao presječno istraživanje. ISPITANICI I METODE. U istraživanje je bilo uključeno 65 pacijentica prosječne dobi 50 godina koje su zaprimljene u Klinički zavod za nuklearnu medicinu i zaštitu od zračenja s kliničkom slikom Gravesove bolesti. Pacijentice su bile podijeljene u dvije skupine: I) pacijentice s Gravesovom bolesti (N = 50) i II) kontrolne ispitanice (N = 15). Koncentracije TSH, FT4 i FT3 izmjerene su mikročestičnom kemiluminiscentnom imunoanalizom (CMIA) na Arhitect i1000SR analizatoru (Abbott Laboratories, Lake Forest, SAD), koncentracije TRAB-a elektrokemiluminiscentnom imunoanalizom (ECLIA) na Cobas e601 analizatoru (Roche Diagnostics GmbH, Mannheim, Njemačka), a TSI kemiluminiscentnom imunoanalizom (CLIA) na Immulite 2000 XPi analizatoru (Siemens Healthcare Diagnostics Inc, Flanders, USA). Rezultati su obrađeni statističkim testom MedCalc, verzija 12.4.0.0. (MedCalc Software, Mariakerke, Belgium). REZULTATI. Pozitivna prediktivna vrijednost (PPV) i negativna prediktivna vrijednost (NPV) za TSI iznosile su 100 %, dok je PPV za TRAB bila 98 %, a NPV 75 %. ROC analizom dobivena je bolja specifičnost i osjetljivost za TSI (površina ispod krivulje 0,997) u odnosu na TRAB (površina ispod krivulje 0,967). ZAKLJUČAK. Rezultati istraživanja pokazali su da je TSI test pouzdaniji za dijagnosticiranje Gravesove bolesti u odnosu na rutinski korišteni TRAB.
Abstract (english)
OBJECTIVES. The aim of this study was to compare the diagnostic significance of TRAB and TSI tests in diagnosing patients with Graves' disease. STUDY DESIGN. Cross-sectional study. PARTICIPANTS AND METHODS. The study included 65 patients of the average age of 50, who were admitted to the Clinical Institute for Nuclear Medicine and Radiation Protection suspected of suffering from Graves' disease. Patients were divided into two groups: I) Graves' disease patients (N=50) and II) control subjects (N=15). Concentrations of TSH, FT4 and FT3 were measured by chemiluminiscent microparticle immunoassay (CMIA) on the Arhitect i1000SR analyzer (Abbott Laboratories, Lake Forest, USA), the TRAB concentration by electrochemiluminiscent immunoassay (ECLIA) on the Cobas e601 analyzer (Roche Diagnostics GmbH, Mannheim, Germany), TSI was measured by chemiluminescence immunoassay (CLIA) on Immulite 2000 XPi analyzer (Siemens Healthcare Diagnostics Inc., Flanders, USA). The results were analyzed in MedCalc, version 12.4.0.0. (MedCalc Software, Mariakerke, Belgium). RESULTS. Positive predictive value (PPV) and negative predictive value (NPV) for TSI were 100%, while PPV for TRAB was 98% and NPV 75%. ROC analysis yielded better specificity and sensitivity for TSI (area under the curve 0.997) compared to TRAB (area under the curve 0.967). CONCLUSION. The results of the study indicated that the TSI test was more reliable for diagnosing Graves' disease than TRAB, which is routinely used.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:963520
Study programmeTitle: University graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra medicinsko laboratorijske dijagnostike (magistar/magistra medicinsko laboratorijske dijagnostike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-11-05 14:17:14