prikaz prve stranice dokumenta Ishodi bolesti i rizični čimbenici seronegativnih spondiloartritisa
  Download
PDF 743.64 KB
master's thesis
Ishodi bolesti i rizični čimbenici seronegativnih spondiloartritisa
2020. urn:nbn:hr:152:457127
Marošević, Antea
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

Cite this document

Marošević, A. (2020). Ishodi bolesti i rizični čimbenici seronegativnih spondiloartritisa (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:457127

Marošević, Antea. "Ishodi bolesti i rizični čimbenici seronegativnih spondiloartritisa." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2020. https://urn.nsk.hr/urn:nbn:hr:152:457127

Marošević, Antea. "Ishodi bolesti i rizični čimbenici seronegativnih spondiloartritisa." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2020. https://urn.nsk.hr/urn:nbn:hr:152:457127

Marošević, A. (2020). 'Ishodi bolesti i rizični čimbenici seronegativnih spondiloartritisa', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 02 April 2025, https://urn.nsk.hr/urn:nbn:hr:152:457127

Marošević A. Ishodi bolesti i rizični čimbenici seronegativnih spondiloartritisa [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2020 [cited 2025 April 02] Available at: https://urn.nsk.hr/urn:nbn:hr:152:457127

A. Marošević, "Ishodi bolesti i rizični čimbenici seronegativnih spondiloartritisa", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:152:457127

Please login to the repository to save this object to your list.
Metadata
TitleIshodi bolesti i rizični čimbenici seronegativnih spondiloartritisa
Title (english)Outcomes and risk factors in seronegative spondyloarthritis
AuthorAntea Marošević
MentorJasminka Milas-Ahić (mentor)
Committee memberVišnja Prus (predsjednik povjerenstva)
Committee memberMira Kadojić (član povjerenstva)
Committee memberJasminka Milas-Ahić (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2020-09-17, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract
Cilj istraživanja: Ciljevi istraživanja bili su ispitati postojanje rizičnih čimbenika za razvoj seronegativnog spondiloartritisa i njihovu povezanost s ishodom, ispitati povezanost tijeka bolesti s ishodom i vrstom terapije te povezanost komorbiditeta s ishodom bolesti. Ustroj studije: presječna studija Ispitanici i metode: U istraživanju je sudjelovalo 150 pacijenata sa seronegativnim spondiloartritisom dijagnosticiranih i praćenih na Zavodu za reumatologiju, kliničku imunologiju i... More alergologiju KBC-a Osijek. Klinički podatci prikupljeni su iz povijesti bolesti. Zabilježeni su dob, spol, osnovna bolest, godina postavljanja dijagnoze, prvi simptomi, HLA-B27 i ostali lokusi, laboratorijski pokazatelji, postojanje radioloških promjena, komorbiditeti, postojanje sakroileitisa i/ili perifernog artritisa, dijagnoza psorijaze kao poseban entitet, godina dijagnoze psorijaze, vrsta terapije, doza glukokortikoidne terapije te indeksi vrijednosti BASFI, ASDAS i BASDAI. Rezultati: Kod žena značajno više prisutni su enteropatski spondiloartritis i nediferencirani spondiloartritis, kod muškaraca ankilozantni spondilitis, dok psorijatični artritis ne pokazuje spolnu predominaciju. Pacijenti s AS-om dominantno su HLA-B27 pozitivni, dok su pacijenti sa PsA-om i SpA-om pokazali slabiju korelaciju. Uz HLA-B27 prisutni su HLA-DRB1*01, HLA-B35 te HLA-DQB1*03. Nismo pronašli povezanost tijeka bolesti s ishodom bolesti ni vrstom terapije. Najčešći komorbiditeti bili su: hipertenzija, gastrointestinalne bolesti, metaboličke i psihijatrijske bolesti. Više od polovice pacijenata prima konvencionalnu terapiju, AS pacijenti češće primaju biološku terapiju, a SpA rjeđe. Vrijednosti BASFI-a, BASDAI-a i ASDAS-a smanjile su se nakon uvođenja biološke terapije, što pokazuje dobar ishod bolesti. Zaključak: Spol, dob i HLA-B27 predstavljaju rizične čimbenike za seronegativne spondiloartritise, a ishodi i kontrola aktivnosti bolesti povoljni su u liječenih pacijenata. Less
Abstract (english)
Objectives: The study aimed to examine the existence of risk factors for the development of seronegative spondyloarthropathies, their correlation with the disease outcomes, the correlation between the course of the disease, outcomes and types of therapy as well as the correlation of underlying comorbidities with the disease outcome. Study Design: cross-sectional study Participants and Methods: The research included 150 patients with seronegative spondyloarthropathies diagnosed and... More monitored at the Institute for Rheumatology, Clinical Immunology and Alergology at Clinical Hospital Center Osijek. Clinical data were collected from medical history. The following patients data were collected and observed: age, sex, primary disease, year of diagnosis, initial symptoms, HLA-B27 and other loci, laboratory findings, radiographic changes, comorbidities, sacroileitis and/or peripheral arthritis, psoriasis and year of diagnosis, type of therapy, dose of glucocorticoid therapy, BASFI, ASDAS and BASDAI. Results: Enteropathic and undifferentiated spondyloarthritis were more common among women, while ankylosing spondylitis was more common in men. There was no statistically significant difference in sex in patients with psoriatic arthritis. Patients with AS are predominantly HLA-B27 positive, while PsA and SpA patients indicate a weaker correlation with HLA-B27. HLA-DRB1*01, HLA-B35 and HLA-DQB1*03 were the other commonly present loci. The research did not find the correlation of the disease course and outcomes with the types of therapy. The most common comorbidities included: hypertension, gastrointestinal, metabolic diseases, and psychiatric diseases. More than half patients received non-biological conventional therapy; patients with AS more commonly received biological therapy, unlike patients with SpA. BASFI, BASDAI and ASDAS values decreased, showing a positive disease outcome. Conclusion: Sex, age and HLA-B27 are the risk factors in seronegative spondyloarthritis. The disease outcomes are favorable and well controlled in observed treated patients. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:457127
Study programmeTitle: University Graduate Studies
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-10-11 08:20:32
accessibility

closeAccessibilityrefresh

If you wish to permanently save changes, click on Save, if not - your settings will be reset when you restart the browser.