Objectives: The study aimed to examine the existence of risk factors for the development of seronegative spondyloarthropathies, their correlation with the disease outcomes, the correlation between the course of the disease, outcomes and types of therapy as well as the correlation of underlying comorbidities with the disease outcome. Study Design: cross-sectional study Participants and Methods: The research included 150 patients with seronegative spondyloarthropathies diagnosed and monitored at the Institute for Rheumatology, Clinical Immunology and Alergology at Clinical Hospital Center Osijek. Clinical data were collected from medical history. The following patients data were collected and observed: age, sex, primary disease, year of diagnosis, initial symptoms, HLA-B27 and other loci, laboratory findings, radiographic changes, comorbidities, sacroileitis and/or peripheral arthritis, psoriasis and year of diagnosis, type of therapy, dose of glucocorticoid therapy, BASFI, ASDAS and BASDAI. Results: Enteropathic and undifferentiated spondyloarthritis were more common among women, while ankylosing spondylitis was more common in men. There was no statistically significant difference in sex in patients with psoriatic arthritis. Patients with AS are predominantly HLA-B27 positive, while PsA and SpA patients indicate a weaker correlation with HLA-B27. HLA-DRB1*01, HLA-B35 and HLA-DQB1*03 were the other commonly present loci. The research did not find the correlation of the disease course and outcomes with the types of therapy. The most common comorbidities included: hypertension, gastrointestinal, metabolic diseases, and psychiatric diseases. More than half patients received non-biological conventional therapy; patients with AS more commonly received biological therapy, unlike patients with SpA. BASFI, BASDAI and ASDAS values decreased, showing a positive disease outcome. Conclusion: Sex, age and HLA-B27 are the risk factors in seronegative spondyloarthritis. The disease outcomes are favorable and well controlled in observed treated patients.