Objectives: To examine the level of medical literacy and patient compatibility, to identify critical points of health literacy and co-operation in terms of age, gender, marital status, level of education, long-term chronic illness and chronic illness. Methods and questionees: In this cross-sectional study, there are 109 questionees who are suffering from various chronicillnesses, and are cared for by the Community Health Care of the Health Center Osijek. The research instrument was a survey questionnaire. The first part of the questionnaire related to social - demographic data. The second part of the questionnaire was made independently with the help of literature, and referrs to health literacy. The third part of the questionnaire is Compliance Questionaire for Rheumatology (CQR5), which is translated and adapted to all chronic illnesses. Results: The Cronbach Alpha health literacy reliability coefficient is 0.910. In health literacy, there are no significant differences in gender and marital status, while questionees of the higher education level are considerably more medically literate (ANOVA, P <0.001). Older subjects have significantly lower health literacy compared to younger subjects (Pearson coefficient of correlation R = -0.215, P = 0.03). The Cronhach Alpha Health Scale ReliabilityCoefficientis 0.776. Patients have a good level of co-operation. There are no significant differences in coexistence with respect to gender and marital status, while questionees of higher educational level are more cooperative. Conclusion: The level of health literacy and the level of coexistence of the examined group is very good. There is no significant difference in health literacy and co- existence in terms of gender and marital status, but there is the age and level of education.