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undergraduate thesis
Antibakterijska aktivnost 5-nitro-8-hydroxyquinolina protiv multirezistentih gram-negativnih bakterija
2018. urn:nbn:hr:152:446321
Stojačić, Vlatka
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Stojačić, V. (2018). Antibakterijska aktivnost 5-nitro-8-hydroxyquinolina protiv multirezistentih gram-negativnih bakterija (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:446321

Stojačić, Vlatka. "Antibakterijska aktivnost 5-nitro-8-hydroxyquinolina protiv multirezistentih gram-negativnih bakterija." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2018. https://urn.nsk.hr/urn:nbn:hr:152:446321

Stojačić, Vlatka. "Antibakterijska aktivnost 5-nitro-8-hydroxyquinolina protiv multirezistentih gram-negativnih bakterija." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2018. https://urn.nsk.hr/urn:nbn:hr:152:446321

Stojačić, V. (2018). 'Antibakterijska aktivnost 5-nitro-8-hydroxyquinolina protiv multirezistentih gram-negativnih bakterija', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 12 December 2024, https://urn.nsk.hr/urn:nbn:hr:152:446321

Stojačić V. Antibakterijska aktivnost 5-nitro-8-hydroxyquinolina protiv multirezistentih gram-negativnih bakterija [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2018 [cited 2024 December 12] Available at: https://urn.nsk.hr/urn:nbn:hr:152:446321

V. Stojačić, "Antibakterijska aktivnost 5-nitro-8-hydroxyquinolina protiv multirezistentih gram-negativnih bakterija", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:152:446321

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Metadata
TitleAntibakterijska aktivnost 5-nitro-8-hydroxyquinolina protiv multirezistentih gram-negativnih bakterija
Title (english)Antibacterial activity of 5-nitro-8-hydroxyquinoline against multidrug resistant gram-negative bacteria
AuthorVlatka Stojačić
MentorDomagoj Drenjančević (mentor)
Committee memberSuzana Mimica-Matanović (predsjednik povjerenstva)
Committee memberJerko Barbić (član povjerenstva)
Committee memberDomagoj Drenjančević (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2018-09-19, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract
Cilj istraživanja: Svrha ovoga istraživanja bila je testirati osjetljivost kliničkih rezultata multirezistentnih bakterija: Escherichia coli ESBL soj, Klebsiella pneumonia ESBL soj i Pseudomonas aeruginosa na 5-nitro-8-hydroxyquinolin disk-difuzijskom metodom, interpretirati rezultate osjetljivosti i usporediti osjetljivost između bakterijskih vrsta. Materijali i metode: U istraživanju je korišteno 50 gram-negativnih izolata tri bakterijske vrste: E. coli, K. pneumoniae i P. aeruginosa dobivenih iz kliničkih rezultata. Nakon uzgoja, pripreme i inkubacije na Mueller-Hintonovom agaru, očitane su zone inhibicija za svaki nasađeni soj. Mjereno je ravnalom u milimetrima i klasificirano sukladno veličini zone u tri kategorije: senzitivan (S), intermedijarno senzitivan (I) i rezistentan (R). Rezultati: Rezultati su pokazali da nitroxolin uspješno i statistički značajno (Hi-kvadrat test, P < 0,001) pokazuje antibakterijsko djelovanje na sve tri bakterijske vrste. Ukupno je 29 (58%) osjetljivih uzoraka od ukupno 50 testiranih izolata. Značajno je više 20 (87%) E. coli, potom K. pneumoniae 8 (66,77%), najmanje P. aeruginosa (7%) . Rezistentni su uzorci značajno češći kod P. aeruginosa (93%), no treba obratiti pozornost da su korišteni podaci EUCAST standarda (European Committee on Antimicrobal Susceptibility Testing) za enterobakterije u ovom radu u nedostatku standarda za nitroxolin i Pseudomonas spp. Zaključak: Rezultati ovoga istraživanja upućuju na poznate spoznaje o osjetljivosti navedenih bakterijskih vrsta na nitroxolin te mogu doprinijeti boljem razumijevanju djelovanja i mogućnosti korištenja antibiotika u svrhe liječenja nekompliciranih urinarnih infekcija.
Abstract (english)
Objectives: The aim of this research is to examine the sensitivity of the clinical results of multi-resistant bacteria: Escherichia coli ESBL strain, Klebsiella pneumonia ESBL strain and Pseudomonas aeruginosa to the 5-nitro-8-hydroxyquinoline disc-diffusion method, as well as to interpret and compare this sensitivity with a variety of other bacterial species. Matherial and method: 50 gram negativne isolates of three bacterial species obtainted from clinical specimens were used for this research. After breeding, preparing and incubation at Mueller-Hinton agar, inhibition zones for each strain were read and measured by the ruler in millimeters. The final results were classified into 3 categories: sensitive (S), intermediate sensitive (I) and resistant (R). Results: Results showed that nitroxolin, successfully (Hi-quadrat test, P <0.001) exhibits statistically significant antibacterial activity on all three bacterial species. There were 29 (58%) susceptible samples from a total of 50 tested isolates, featuring significantly more E. coli 20 (87%), then follows K. pneumoniae 8 samples (66.77%) whereas P. aeruginosa was least represented with 7%. Resistant samples were more frequent with P. aeruginosa (93%), but it should be taken ino account that the standards used were those for enterobacteria in the absence of standards for nitroxolin and Pseudomonas spp. Conclusion: The results of this study refer to known facts of the sensitivity of these bacterial species to nitroxolin and can contribute to a better understanding of the effects and the options for the use of antibiotics in the treatment of uncomplicated urinary infections.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:446321
Study programmeTitle: University undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni prvostupnik/prvostupnica (baccalaureus/ baccalaurea) medicinske laboratorijske dijagnostike (sveučilišni prvostupnik/prvostupnica (baccalaureus/ baccalaurea) medicinske laboratorijske dijagnostike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2018-12-13 12:06:14