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undergraduate thesis
Utjecaj primjene blokatora angiotenzin II AT-1 receptora (losartana) na izražaj proteina superoksid dismutaze i katalaze u krvnim žilama Sprague-Dawley štakora
2018. urn:nbn:hr:152:303444
Marinčić, Ana
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Marinčić, A. (2018). Utjecaj primjene blokatora angiotenzin II AT-1 receptora (losartana) na izražaj proteina superoksid dismutaze i katalaze u krvnim žilama Sprague-Dawley štakora (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:303444

Marinčić, Ana. "Utjecaj primjene blokatora angiotenzin II AT-1 receptora (losartana) na izražaj proteina superoksid dismutaze i katalaze u krvnim žilama Sprague-Dawley štakora." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2018. https://urn.nsk.hr/urn:nbn:hr:152:303444

Marinčić, Ana. "Utjecaj primjene blokatora angiotenzin II AT-1 receptora (losartana) na izražaj proteina superoksid dismutaze i katalaze u krvnim žilama Sprague-Dawley štakora." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2018. https://urn.nsk.hr/urn:nbn:hr:152:303444

Marinčić, A. (2018). 'Utjecaj primjene blokatora angiotenzin II AT-1 receptora (losartana) na izražaj proteina superoksid dismutaze i katalaze u krvnim žilama Sprague-Dawley štakora', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 18 November 2024, https://urn.nsk.hr/urn:nbn:hr:152:303444

Marinčić A. Utjecaj primjene blokatora angiotenzin II AT-1 receptora (losartana) na izražaj proteina superoksid dismutaze i katalaze u krvnim žilama Sprague-Dawley štakora [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2018 [cited 2024 November 18] Available at: https://urn.nsk.hr/urn:nbn:hr:152:303444

A. Marinčić, "Utjecaj primjene blokatora angiotenzin II AT-1 receptora (losartana) na izražaj proteina superoksid dismutaze i katalaze u krvnim žilama Sprague-Dawley štakora", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:152:303444

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TitleUtjecaj primjene blokatora angiotenzin II AT-1 receptora (losartana) na izražaj proteina superoksid dismutaze i katalaze u krvnim žilama Sprague-Dawley štakora
Title (english)The effect of blocade of angiotensin II AT-1 receptors losartan on the protein expression of superoxide dismutase and catalase in blood vessels of Sprague-Dawley rats
AuthorAna Marinčić
MentorInes Drenjančević (mentor)
Committee memberIvana Jukić (predsjednik povjerenstva)
Committee memberMartina Mihalj (član povjerenstva)
Committee memberInes Drenjančević (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2018-09-26, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract
Cilj: Pomoću Western blot metode utvrditi razliku u izražaju proteina katalaze i superoksid dismutaze 2 u cerebralnim krvnim žilama kod zdravih Sprague-Dawley štakora koji su primali losartan u vodi za piće. Materijali i metode: Zdravi SD štakori starosti 11 tjedana hranjeni su standardnom hranom (0,4 % NaCl), a podijeljeni su u dvije skupine, kontrolnu (CTRL, zdravi netretirani štakori, n=18) i CTRL+LOSARTAN skupina koja je u vodi za piće primala 40 mg losartana dnevno tijekom sedam dana. U uzorcima krvnih žila mozga Western blot metodom određen je izražaj proteina superoksid dismutaze 2 i katalaze. Rezultati: Izražaj proteina superoksid dismutaze 2 i katalaze nije se statistički značajno promijenio u CTRL+LOSARTAN skupini u odnosu na CTRL. Zaključak: Unos losartana u organizam neće značajno utjecati na izražaj proteina superoksid-dismutaze 2 i katalaze u krvnim žilama mozga Sprague-Dawley štakora.
Abstract (english)
Objectives: Using the Western blot method to determine the difference in the expression of catalase and superoxide-dismutase 2 proteins in cerebral blood vessels of Sprague-Dawley rats with or without Losartan treatment in drinking water. Materials and methods: Healthy SD rats aged 11 weeks fed with standard food (0,4 % NaCl) were separated into two groups, control (CTRL, healthy Sprague-Dawley rats, n=18) and CTRL+LOSARTAN group which received 40 mg of Losartan per day in drinking water for 7 days, n=18. The expression of superoxide dismutase 2 and catalase in cerebral blood vessels was determined using the Wester blot method. Results: The expression of superoxide dismutase 2 and catalase proteins hasn't statistically changed in the CTRL+LOSARTAN group compared to the CTRL group. Conclusion: Intake of Losartan in the organism will not significantly affect the superoxide dismutase 2 and catalase proteins expressions in the cerebral blood vessels of the Sprague-Dawley rats.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:303444
Study programmeTitle: University undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni prvostupnik/prvostupnica (baccalaureus/ baccalaurea) medicinske laboratorijske dijagnostike (sveučilišni prvostupnik/prvostupnica (baccalaureus/ baccalaurea) medicinske laboratorijske dijagnostike)
Type of resourceText
File originBorn digital
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Created on2019-01-08 10:08:51