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doctoral thesis
Ekspresija Nectin-4 proteina u luminalnim B, HER2 negativnim karcinomima dojke
2017. urn:nbn:hr:152:312080
Rajc, Jasmina
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Rajc, J. (2017). Ekspresija Nectin-4 proteina u luminalnim B, HER2 negativnim karcinomima dojke (Doctoral thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:312080

Rajc, Jasmina. "Ekspresija Nectin-4 proteina u luminalnim B, HER2 negativnim karcinomima dojke." Doctoral thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2017. https://urn.nsk.hr/urn:nbn:hr:152:312080

Rajc, Jasmina. "Ekspresija Nectin-4 proteina u luminalnim B, HER2 negativnim karcinomima dojke." Doctoral thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2017. https://urn.nsk.hr/urn:nbn:hr:152:312080

Rajc, J. (2017). 'Ekspresija Nectin-4 proteina u luminalnim B, HER2 negativnim karcinomima dojke', Doctoral thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 10 December 2024, https://urn.nsk.hr/urn:nbn:hr:152:312080

Rajc J. Ekspresija Nectin-4 proteina u luminalnim B, HER2 negativnim karcinomima dojke [Doctoral thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2017 [cited 2024 December 10] Available at: https://urn.nsk.hr/urn:nbn:hr:152:312080

J. Rajc, "Ekspresija Nectin-4 proteina u luminalnim B, HER2 negativnim karcinomima dojke", Doctoral thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:152:312080

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Metadata
TitleEkspresija Nectin-4 proteina u luminalnim B, HER2 negativnim karcinomima dojke
Title (english)Expression of Nectin-4 protein in luminal B (HER2 negative) breast cancer
AuthorJasmina Rajc
MentorDamir Gugić (mentor)
Committee memberKsenija Marjanović (predsjednik povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2017-09-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
Cilj istraživanja: Istražiti povezanost ekspresije Nectin-4 proteina u populaciji pacijenata s luminalnim B HER2 negativnim podtipom karcinoma dojke a u korelaciji sa prognostičkim parmetrima kao što su intenzitet hormonskih receptora, Ki-67 proliferacijski indeks, dob, veličiina i histološki gradus tumora te zahvaćenost pazušnih limfnih čvorova. Materijal i metode: Ispitivana je skupina od 147 pacijenata operiranih u KBC Osijek sa unilateralnim karcinomom dojke bez dokazanih udaljenih metastaza, koji se prema najnovijoj St. Gallenskoj klasifikaciji svrstavaju u luminalnu B HER2 negativnu podskupinu. Korištenjem arhivskih parafinskih kocaka učinjeno je imunohistokemijsko bojanje antitijelom na Nektin-4 protein, a rezultati su korelirani sa kliničkim podatcima uz Kaplan-Meier krivulje te Cox-ovu regresijsku analizu. Rezultati: Dokazana je statistički značajna povezanost ekspresije Nektina-4 sa veličinom tumora (p<0.05; Chi-Square Test) te negativna povezanost ukupnim preživljenjem, prežvljenjem bez bolesti, te preživljenjem bez pojave udaljenih metastaza (p<0,001; Kaplan-Meier). U Cox-ovoj univarijantnoj i multivarijantnoj analizi pokazao se kao statistički značajan nezavisni faktor za sveukupno preživljenje i preživljenje bez povrata bolesti (p<0,001). Nije uočena statistički značajna povezanost ekspresije Nektina-4 sa dobi, ekspresijom estrogenskih i progesteronskih receptora, zahvaćenošću pazušnih limfnih čvorova, diferencijacijom tumora, histološkim tipom i Ki-67 proliferacijskim indeksom. Zaključak: Nectin-4 je važan prognostički pokazatelj te potencijalna meta za nove terapijske metode u liječenju luminalnih B HER2 negativnih karcinoma dojke.
Abstract (english)
Objectives: The aim of this study was to evaluate an expression of Nectin-4 in luminal B (HER2 negative) breast cancer, in correlation with other prognostic parameters as hormone positivity, Ki-67 proliferation index, age, tumor size, histological grade and axillary lymph node status. Patients and methods: In this retrospective study clinical and pathological parameters of 147 luminal B (HER2 negative) breast cancers have been examined from the patients who had undergone a surgery at the University Hospital Osijek. These patients were presenting with primary unilateral breast cancer with no evidence of distant metastasis. Nectin-4 protein expression was assessed by immunohistochemistry and the results were correlated with the clinical data using Kaplan-Meier curves and univariante and multivariate stepwise proportional-hazard analysis (Cox model). Results: Nectin-4 overexpression was significantly correlated with tumor size (p<0.05; Chi- Square Test), also Nectin-4 expression was negatively associated with overall survival, disease free survival and distant relapse free survival with the same significance (p<0,001; Kaplan-Meier). Cox analysis has shown statistically significant correlation between Nectin-4 and overall and disease free survival (p<0,001). Statistically significant correlation between Nectin-4 and age, ER, PR, age, lymph node metastasis, tumor differentiation, histological subtype and Ki-67 proliferation index was not found. Conclusion: Nectin-4 is relevant prognostic factor and a therapeutic target in luminal B (HER2 negative) breast cancer.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:312080
Study programmeTitle: University Postgraduate Study
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-11-17 10:11:00