Objectives: To describe the course of trichinellosis infection and the characteristics of disease control, as well as to investigate the clinical, hematological, biochemical, and serological features of patients with trichinellosis. Additionally, to examine the nexus between laboratory findings and the clinical presentation of patients, and to compare the results obtained during the admission of patients to the emergency room of the Clinic for Infectious Diseases at the Clinical Hospital Centre in Osijek during the 2021 trichinellosis epidemic, with the findings during follow-up examinations. Study design: Historical cohort study. Patients and methods: The study includes 20 patients with confirmed trichinellosis in the year 2021, recruited from the Osijek-Baranja County region and treated at the Clinic for Infectious Diseases, Clinical Hospital Centre Osijek. Data regarding clinical symptoms and laboratory findings were collected from available medical records at the Clinic for Infectious Diseases. Statistical analysis was performed using the MedCalc software program. Results: There is a significant difference in the laboratory findings analyzed during the initial and follow-up examinations, specifically in lactate dehydrogenase, creatinine, creatine kinase, Creactive protein, and troponin I values. However, there is no significant difference in the values of leukocytes, eosinophils, as well as aspartate and alanine aminotransferase. Conclusion: The observed values during the initial examination of patients in the Emergency Infectious Disease Clinic were as expected and consistent with the typical clinical and laboratory profile of trichinellosis. After antiparasitic therapy, there is a clinically noticeable improvement in the patients' condition, with laboratory results showing a decrease in the values of previously elevated observed parameters, as well as a reduction in the number of patients whose values were elevated, i.e., they returned within the reference range.