Background: The aim of this study was to determine expression of MUC2 and VEGF in the mucosa tissue in patients with Barrett esophagus, then patients with diagnose of esophageal carcinoma and to determine whether expression of MUC2 and VEGF in the BE mucosa may be useful in determining dysplasia. We also tried to determine whether existence of Helicobacter pylori in affected mucosa caused increased risk for BE and adenocarcinoma. Barrett's esophagus is a precancerous lesion whose appearance in the modern world constantly rise. The importance of this disease is in the fact that precancer sequence have three degree : metaplasia-dysplasia-adenocarcinoma. The expressiveness of the glycoprotein MUC2 and VEGF in the mucosa of Barrett esophagus may be associated with a higher risk of developing esophageal adenocarcinoma. Almost 95% of patients who develop cancer of esophagogastric junction did not know that they suffer from BE , and that the evolution of BE to cancer last 20-30 years. Materialis and methods: The study included 36 patients with diagnose of BE short segments with intestinal metaplasia and / or dysplasia after unsuccessful treatment with proton pump inhibitors. The diagnosis was confirmed by histopathological analysis and the expression of MUC2 and VEGF by immunohistochemistry analysis Results: Study have confirmed the MUC2 positivity of goblet cells, and VEGF as a basis for creation of the vascular network in the metaplastic altered cells of BE. We found four patients in the early stage of esophageal adenocarcinoma (all underwent surgical resection), 32 patients with BE; five of them had conditions for APC, one for the RFA, one for EMR, and 25 of them were treated with PPI's. After the treatment, the control histological and imunohistochemistry analysis confirmed the regression of BE in 25 subjects. Treatment with PPI's substantially had influence in reduction of VEGF between the two views, but had no effect in reducing MUC2, which was negative after ablative techniques such as RFA and EMR. Based on the parameter MUC2 , we could not distinguish subjects with CA from those with BE. The reason lied in the fact that MUC2 was presented in goblet cells of BE and CA. Also, based on the parameter of VEGF, we could not distinguish subjects with CA from those with BE. The reason lied in the fact that the presence of VEGF was presended in BE and in the CA esophagus. With Fisher exact test, we compared the expression of MUC2 between DY positive and DY negative subjects, then the difference in the intensity of VEGF between DY positive and DY negative and the difference in the intensity of HP. In all three analyzes between DY positive and DY negative we did not found a statistically significant diference. The reason probably lied in a small sample of subjects who had a positive finding of dysplasia. Based on severity of bacteria HP in the esophageal mucosa, we could distinguish subject with CA and those with BE, among which those with the CA had a smaller expression of HP. Conclusion: MUC 2 positivity is characteristic for goblet cells of Barrett's esophagus, but not the only biomarker. VEGF is an indicator of angiogenesis in the mucosa of Barrett's esophagus, with / or without an IM and low grade DY. The role of H pylori was protecting to the mucosa of the esophagus. This dissertation indicates for more frequent intake of bioptic samples from the EG junction in patients with minimal endoscopic changes in the mucosa. Classic histopathologic analysis showed the benefit of the additional immunohistochemical analysis of MUC2 and VEGF, as indicators for development of an cancer. Teraphy with proton pump inhibitors is still basic protocol for the treatment, with the introduction and development of ablative techniques such as ASF, RFA, EMR.